Megadose methylprednisolone effect on myelofibrosis and granulocyte-macrophage colony-stimulating factor.
نویسنده
چکیده
Prof. Dr. Șinasi Özsoylu, Hacettepe Children’s Hospital, TR-06100 Ankara (Turkey) Borba et al. [1] in their paper entitled ‘Neutropenia associated with myelofibrosis in systemic lupus erythemato-sus’ stated: ‘It is important to emphasize that although it has been reported that fibrosis could be reversed by steroid therapy, only in 2 cases fibrosis remitted following this treatment’. We have reported that bone marrow fibrosis could be reversed in children and adult patients with myelofibrosis by megadose methylprednisolone (MDMP) [2-5], as was also shown recently by Inoue et al. [6]. I would like to add that recently MDMP has been used orally which is cheaper and more convenient to the patients, and is as effective as the intravenous route [7]. On this occasion, may I also indicate that the stimulating effect of MDMP on chemotherapyinduced granulocy-topenia in patients with leukemia [8] was not cited by Moriyama et al. [9] in their related paper. Elevation of endogenous granulocyte-macrophage colony-stimulating factor related to MDMP treatment was also shown by our group [10]. I am aware that the MDMP effect on myelofibrosis was published only recently in this journal [11]. Despite all my effort, I consider Wiktor-Jedrzejczak’s point that ‘some references are less equal than others’ should be appreciated [12].
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عنوان ژورنال:
- Acta haematologica
دوره 91 1 شماره
صفحات -
تاریخ انتشار 1994